清末(mò )民初,佛山武(wǔ )学宗师(shī )黄飞鸿因噩梦预感女记者莫(mò )十三遇(yù )险,携弟子前往古云村寻人。村(cūn )中蜈蚣(gōng )教借蛊术胁迫村民献祭孩童,莫十三(sān )探查真(zhēn )相时被擒,身中噬魂蛊。黄飞鸿(hóng )闯祭坛(tán )救人,因不忍伤及被蛊惑的村(cūn )民反中(zhōng )蛊毒,幸得卧底蜈(wú )蚣教的鬼脚(jiǎo )七暗中(zhōng )相助。众人合力破(pò )除水源蛊毒(dú ),救治村(cūn )民,鬼脚七伤愈拜师。巫师自焚(fén )后,线索(suǒ )指向广州东瀛会馆。黄飞鸿潜(qián )入会馆(guǎn )救出被掳孩童,对决主事服部(bù )一郎,得(dé )知幕后黑手为西洋吸血鬼麦克罗。麦(mài )克罗散(sàn )播疫毒祸乱羊城,以莫十三性(xìng )命相要(yào )挟。黄飞鸿于绝境(jìng )中融合腿法(fǎ ),悟出佛(fó )山无影脚,击杀麦(mài )克罗。蛊毒尽(jìn )解,百姓(xìng )恢复神智,广