清末民初,佛山武学宗师黄飞鸿因噩(è )梦预感女记者莫十三遇(yù )险,携弟子前(qián )往古云(yún )村寻人。村中蜈蚣(gōng )教借蛊术胁(xié )迫村民(mín )献祭孩童,莫十三(sān )探查真相时(shí )被擒,身(shēn )中噬魂蛊。黄飞鸿(hóng )闯祭坛救人(rén ),因不忍(rěn )伤及被蛊惑的村(cūn )民反中蛊毒(dú ),幸得卧(wò )底蜈蚣教的鬼脚七暗中相助。众人合(hé )力破除水源蛊毒,救治村民,鬼脚七伤(shāng )愈拜师。巫师自焚后,线索指向广州东(dōng )瀛会馆。黄飞鸿潜入会馆(guǎn )救出被掳孩(hái )童,对决(jué )主事服部一郎,得(dé )知幕后黑手(shǒu )为西洋(yáng )吸血鬼麦克罗。麦(mài )克罗散播疫(yì )毒祸乱(luàn )羊城,以莫十三性(xìng )命相要挟。黄(huáng )飞鸿于(yú )绝境中融合腿法(fǎ ),悟出佛山无(wú )影脚,击(jī )杀麦克罗。蛊毒尽解,百姓恢复神智,广(guǎng )